By Dr. R. J. Wurtman (auth.), Prof. Dr. Konrad Maurer, Prof. Dr. Peter Riederer, Prof. Dr. Helmut Beckmann (eds.)
The publication Alzheimer's disorder - Epidemiology, Neuropathology,Neurochemistry, and Clinics is derived from a global Symposium at the get together of the a hundred and twenty fifth Anniversary of the delivery of Alois Alzheimer (14.6.1864-19.12.1915). over the last decade, because the aged became the fastest-growing section of the inhabitants in industrialized international locations, Alzheimer's affliction has emerged as one of many significant psychological illnesses. The members to this e-book symbolize across the world famous experts within the box of dementia and current new information regarding epidemiology, neuropathology, neurochemistry, and clinics in Alzheimer's ailment. This booklet is a wealthy and precious updated source for psychiatrists, neurologists, scientists operating within the fields of neuropathology, neurochemistry and molecular genetics, behavioral scientists, family members physicians and all who percentage an curiosity in knowing and treating the older person with Alzheimer's disease/dementia.
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Extra info for Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics
With his description he gave an account of the disease which is still valid today: the clinical aspect of a progressive loss of cognitive, mnestic and language functions and the neuropathological aspect of a degeneration of 24 H. Hafner ganglia and an agglomeration of neurofibrillary tangles and plaques in the cerebral cortex and in the hippocampus. The establishment of an exact diagnosis of dementia of Alzheimer's type still requires positive findings in both clinical and neuropathological fields.
As shown in this Fig. there was a considerable individual variation in the dopamine level in the substantia nigra of these individuals, who may be considered to have been essentially normal for the age (72 - 91 years), with respect to the brain, except for one individual who had Parkinson's 18 A. Carlsson disease, and a few patients who had mild dementia, possibly to be considered normal for the age. This illustrates a considerable individual variation in the sensitivity to the mechanisms leading to the age dependent loss of dopamine neurons.
Arch Neurol 39:570-575 Shalat SL, Selzer B, Pidcock C, Baker EL (1986) A case-control study of medical and familial history and Alzheimer's disease. Am J Epidemiol 124:540 Shore D, Wyatt R J (1983) Aluminium and Alzheimer's disease. J Nerv Ment Dis 171: 553-558 Sternberg E, Gawrilowa S (1978) Uber klinisch-epidemiologische Untersuchungen in der sowjetischen Alterspsychiatrie. Nervenarzt 49:347-353 St. George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, eta! (1987) The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics by Dr. R. J. Wurtman (auth.), Prof. Dr. Konrad Maurer, Prof. Dr. Peter Riederer, Prof. Dr. Helmut Beckmann (eds.)