By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)
The ebook comprises unique articles and studies provided on the sixth overseas iciness convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention was once to offer and speak about fresh facts at the interface among neuroimmunology and neurodegeneration, particularly susceptibility to autoimmune and neurodegenerative tactics, neuroprotection and restorative therapy thoughts. those concerns have been mentioned within the gentle of contemporary advancements in a number of sclerosis, Parkinson’s disorder, amyotrophic lateral sclerosis, Huntington’s disorder and multisystem atrophy. The articles spotlight issues, that are relatively attention-grabbing for the clinician and the neuroscientist. a few of the neuroprotective thoughts have already been built or are at this time clinically investigated. The neuroprotective function of deep mind stimulation, antiglutamatergic treatment and apomorphine should be established in medical reviews within the close to destiny. this is often additionally the case for destiny healing ways to recovery of the broken apprehensive method, equivalent to somatic gene remedy, implantation of genetically changed cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the position of the glia, which turns out to play a key position, either in typically as neuroimmunological and neurodegenerative problems labeled illnesses, as indicated above. the themes mentioned within the booklet are major for contemporary advancements in scientific neurology and neuroscience, as proven within the present literature and at foreign congresses.
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Extra resources for Advances in Research on Neurodegeneration: Volume 6
Nat Genet 13: 477480 Kurtzke J (1985) Epidemiology of multiple sclerosis. In: Vinken PJ, Bruyn GB, Klawans HL, et al (eds) Handbook of clinical neurology, vol 3: Demyelinating diseases. Elsevier, Amsterdam, pp 259-287 Kurtzke JF (1993) Epidemiologic evidence for multiple sclerosis as an infection. Clin Microbiol Rev 6: 382-427 Marrosu MG, Muntoni F, Murru MR, Spinicci G, Pischelda MP, Goddi F, Cossu P, Pirastu M (1988) Sardinian multiple sclerosis is associated with HLA-DR4: a serological and molecular analysis.
Finally in a 6 month double-blind parallel-group trial, ropinirole has also been compared with bromocriptine in 555levodopa-treated patients. Both agonists had a very similar symptomatic effect in term of efficacy as well as safety (Ropinirole 043 Study Group, 1996). Although the results have sometimes been presented as in favor of the "newer" agents, compared to the "older" reference drug, none of these 3 trials provides any statistically significant difference which could consistently support the superiority of ropinirole, pramipexole or cabergoline over bromocriptine in this indication.
J Neur Neurosurg Psychiatry 57: 1034-1038 Murer MG, Dziewczapolski G, Menalled LB, Garcia MC, Agid Y, Gershanik 0, Raisman-Vozari R (1998) Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol 43: 561-575 Nutt JG (1990) Levodopa-induced dyskinesia. Neurology 40: 340-345 Olanow CW (1990) Oxidation reactions in Parkinson's disease. Neurology 40: S32S39 Pearce RKB, Banerji T, Jenner P, Marsden CD (1998) De novo administration of ropinirole and bromocriptine induces less dyskinesia than L-dopa in the MPTPtreated marmoset.
Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)