By Donald J. Hanahan
This publication presents a concise advent to phospholipid chemistry and is meant for a wide viewers of biologists, biochemists, and graduate scholars. constructed as a part of a graduate path on lipids, this booklet additionally serves as a reference for laboratory investigators on sign transduction and organic membranes. the 1st a part of the textual content is dedicated to an orientation to the chemical nature of lipids ordinarily, how they're regarded as linked within the mobilephone, and the technique wherein the mobile lipids (including the phospholipids) might be recovered from cells and subjected to an preliminary id. next chapters signify the choline-containing phospholipids, together with the sphingolipids, the non-choline containing phospholipids, and eventually, the so-called minor phospholipids. The latter compounds, which act as agonists or lipid chemical mediators on cells, shape a forefront of a brand new class of biologically lively components and feature set the examine of mobile phospholipids on a brand new and exiting direction. most significantly, this e-book offers a foundation for extra inquiry on those advanced molecules, exhibiting that even though the compounds are specified, with care and figuring out, they are often studied comfortably
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Additional resources for A Guide to Phospholipid Chemistry
No longer are these compounds viewed as passive components, mainly functioning as semipermeable barriers for cation/anion transfer. A few representative examples follow of phospholipid involvement in certain cellular events. Cofactor Behavior Two examples will be given in which phospholipids can be considered as cofactors which do not undergo any chemical alteration. Interestingly in both of these examples, a charged phospholipid or phospholipid mixture is required and the effect can be quite dramatic.
The two eluates are combined, phased by the addition of water, and then the chloroform-rich layer is removed and evaporated to dryness under nitrogen. The residue is dissolved in chloroform-methanol (2:1, v/v) and made to volume in a glass-stoppered volumetric flask. This same extraction technique can be applied to erythrocytes, neutrophils, and other comparable cells. A similar approach also can be used with tissues (such as liver and spleen) employing 7-8 ml chloroform-methanol-water per gram of homogenized tissue.
Of particular importance is that even a casual examination of these data will show that the total choline-containing phospholipids were nearly identical. There were no overt differences in the composition of the non-choline-containing phosphoglycerides. While no evidence is at hand to explain the cell's compensatory mechanism, it is obvious that the cell has the ability to try to maintain a "normal" composition. A final example of the uniqueness of phospholipid structure and composition in cells relates to the fatty acyl (or the hydrocarbon moiety) groups of particular lipid species in cells.
A Guide to Phospholipid Chemistry by Donald J. Hanahan